Small cbd oil with green marijuana leaf
19 Jan 2024

Exploring CBD Nebulization: the Potential of 7 Common Delivery Methods

In the field of CBD applications, nebulisation technology is becoming an increasingly popular mode of drug delivery. Nebulisation is able to convert CBD into tiny particles for easy absorption in the lungs and improved bioavailability.

7 Common Delivery Methods Of CBD Nebulisation

There are a total of 7 common ways of CBD nebulisation, either by selecting one of the 3 common nebulisation methods, or by directly selecting one of the 4 common inhalation preparations.

1. Compression Atomisation

Compression atomisation, also known as jet atomisation, is based on the Venturi (Venturi) jet principle, the use of compressed air through a small tube mouth to form a high-speed airflow, resulting in a negative pressure driven by the liquid or other fluids together with the jet to the obstruction in the high-speed impact to the surrounding splash so that the liquid droplets into a mist of particles from the air outlet pipe out.

CBD can be dissolved in the MCT and other oil solutions, the use of high-pressure airflow will be dispersed into a fine particles of 10um or less. The CBD oil solution is broken up by high pressure airflow into fine particles of less than 10 um, which are inhaled by the human body after deceleration. However, the oil solution inhaled into the lungs after the experience is very poor, and may have damage to the lungs.

2. Ultrasonic Nebulisation

Ultrasonic nebulisation is the use of ultrasonic directional pressure, so that the liquid surface bulge, cavitation occurs around the bulge of the liquid surface, so that the liquid is atomised into small molecules of the aerosol.

The oscillation frequency of the ultrasonic nebuliser is 1.7MHz or 2.4MHz, which exceeds the range of human hearing, and the electronic oscillation is harmless to human body and animals, and the equipment is resonated by the high frequency of the ceramic nebuliser, which breaks up the molecular structure of the liquid water and produces the natural floating water mist.

In addition, in the atomisation process will release a large number of negative ions, and its floating in the air smoke, dust and other electrostatic reaction, so that the precipitation of the CBD ultrasonic atomisation products are mostly conceptual hydration cosmetics, 1mg CBD can be solubilised to 1-3ml of water in the liquid, the atomisation time of 30min, and due to the solubilisation of a large number of additives, the inhalation experience is very poor. Most commercially available products are cosmetic hydration products, which cannot play a therapeutic role.

3. Heating Atomisation

Heating nebulisation is to heat the drug directly, so that it sublimates into a gas for inhalation. The most used in medicine for anaesthetics, enflurane, isoflurane, sevoflurane, etc., through direct heating to produce aerosols, inhaled to achieve the effect of general anaesthesia or local anaesthesia.

CBD atomised products on the market are mostly electronic cigarettes, whose boiling point is between 410-500 ° C. The possibility of CBD heating and atomisation into a drug is large, but it needs to be in the design of the heating system and the atomisation system and the precise coordination of efforts.

glass jar contain cbd oil

4. Inhalation Powder Aerosol

Inhalation powder aerosol refers to micronised drugs or with the carrier in the form of capsules, blisters or multi-dose storage, the use of special dry powder inhalation device, the patient’s active inhalation of nebulised drugs to the lungs of the preparation.

CBD powder is very easy to agglomerate, the experiment is by ball milling, water-liquid ball milling, airflow crushing and other ways to reach the size of about 20um, it is difficult to meet the requirements of inhalation preparations.

5. Inhalation Aerosol

Inhalation aerosol refers to the drug-containing solutions, emulsions or suspensions and suitable projectile agent together in a pressure-resistant container with a special valve system, the use of the pressure of the projectile agent will be sprayed into the contents of the mist, inhalation to play a local or systemic therapeutic effect.

CBD hydrophobic, made of aerosol need to be added to the surface of the active agent or co-solvent, CBD in the projection is almost insoluble, need to be aided by the solubility of ethanol, so the way of drug loading is extremely low. CBD is almost insoluble in the spray and needs to be solubilised with the help of ethanol.

6. Inhalation Spray

Inhalation sprays can be divided into: solution, emulsion and suspension according to the prescription composition. Spray prescription composition and aerosol comparison, in addition to the absence of projectile, other components are basically the same.

Spray is generally composed of drugs, solvents, co-solvents, surfactants, sometimes according to the different physicochemical properties of the drug to join the stabiliser. If the use of preservatives, should be concerned about its impact on safety. CBD in inhalation sprays is similar to aerosol, there are problems such as low drug loading capacity, particle size control difficulty.

7. Nebulised Inhalation Liquid

Nebulised inhalation solution is a drug configured as an aqueous or oil solution, which is nebulised into small droplets of less than 5um using the pressurised or ultrasonic nebuliser described above. It is usually used in conjunction with a nebuliser. CBD to be made into a nebulised inhalation solution requires the addition of a large amount of surface activator or oil solution, which has a low drug loading capacity and a high impact on the lungs when inhaled.

CBD nebulisation is an efficient way of delivering the drug, but there are advantages and disadvantages to different nebulisation methods and inhalation formulations. Overall, CBD is most likely to be delivered by heated nebulisation, but requires effort in the design and precise fit of the heating and nebulising systems.


When choosing a CBD nebulisation product that suits your needs, you need to fully understand the characteristics of the various modalities and the applicable scenarios. In the future, with the advancement of technology, CBD nebulisation products will better serve the majority of patients, providing them with a more convenient and effective treatment experience.

Editorial Guidelines: This article is informational and not a replacement for professional medical advice. Consulting a healthcare provider is recommended before beginning any new supplement regimen.